Acording to research, 70%~80% of Mesothelioma caused by previous exposure to asbestos. Working under the asbestos environment , or living in inbound asbestos exposure for long period have high posibility to get Mesothelioma. However, in rare cases, even exposure to asbestos environment for a months may cause Mesothelioma.
The posibility of Mesothelioma recurrence is high compare to other disease. All the expert doctor still working hard on the research for better result. They are tring their best to get more Mesothelioma Information to help the patient.
On the other hand, many people suffering from the after-effects of asbestos may or may not find themselves under worker's compensation law. In the additions, the Mesothelioma getting worse day to day and the huge madicine cost will be a big burden for the family.
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Mesothelioma Medicine
Peritoneal Mesothelioma - Summary, Diagnosis & Treatment
[Summary]
Peritoneal malignant mesothelioma, also known as primary peritoneal mesothelioma, and originated in peritoneal mesothelial organizations epithelial tumors. This rare disease than pleural mesothelioma, slightly higher than the male female. Etiology and asbestos exposure, the incidence and contacts for a long interval, and often in more than 30 years. Mesothelioma often benign single, located in the fallopian tubes, uterus top of the peritoneum, rare in other parts. Often diffuse malignant mesothelioma, covering all or part of peritoneal
[Diagnosis]
1. History questions
The exact cause of the abdominal pain, abdominal distension and gastrointestinal disorders, abdominal pain may be in for diversification, but the pain of the stubbornness of its common characteristics. The high incidence of ascites, in more than 90 per cent, in a longer or shorter period of abdominal pain, ascites suddenly appeared, but also in the early ascites appeared individually. The amount of ascites and stubborn. General situation in the longer term, little change, loss of appetite can be maintained, wasting not obvious, no fever, sometimes spontaneous hypoglycemia can occur. Can be associated with chest pain, difficulty breathing, coughing and other symptoms of pleural mesothelioma.
2. Medical examination found
Peng Long abdomen, or a frog belly, mobility voiced positive abdominal palpation can be touched on the size ranging from single or multiple masses, the general tenderness not obvious. As with pleural mesothelioma, pleural effusion can be found positive signs.
3. Laboratory examination
B-ultrasound and CT, can be found thin sheet of images and ascites tumor. Ascites for exudate, but also for the courage and uprightness. Hyaluronic acid such as ascites increased to 120 ug / ml, very helpful in the diagnosis. Ascites find new biological diagnosis of mesothelioma cells, but also the middle of the mesothelial cells of ascites chromosome analysis, help diagnosis. Laparoscopic seized visible peritoneal surface filled with plaques and nodules, and biopsy examination to confirm the diagnosis. It must be noted and tuberculous peritonitis, peritoneal metastasis of identification.
[Treatment]
General chemotherapy and radiotherapy are not satisfied with the results. Some reports in recent years with adriamycin treatment, 50% of cases of extended survival period, but there are also reports considered invalid. It was also advocate the use of immune therapy, needed further observation. General in the diagnosis of 1 ~ 2 years after death.
Peritoneal Mesothelioma - History
There is a lot of depressing information on the internet about peritoneal mesothelioma and the survival associated with this cancer. Reading it you would think that no one has ever survived peritoneal mesothelioma beyond a year or so. This information is far from comprehensive. To help balance some of the negative information that is so prevalent on the Web, we present some case histories of long-term peritoneal mesothelioma survival as published in the peer reviewed medical literature.
9 Years +
In November 1979, a 73 year-old man had abdominal pain and distension and was found to have an abdominal mass. A laparotomy was performed that revealed peritoneal malignancy with ascites. A biopsy demonstrated that the tumor was malignant peritoneal mesothelioma. No special treatment was recommended other than draining of the ascites. In spite of the continuing ascites and the gradually-enlarging abdominal masses, the patient enjoys good health, and lives independently at home. How many more years (in excess of 9) this patient lived with peritoneal mesothelioma is not known.
See: Norman, P.E. and Whitaker, D., Nine-Year Survival in a Case of Untreated Peritoneal Mesothelioma, Med J Aust 1989; 150: 43-44.
15 Years +
A woman was diagnosed with peritoneal mesothelioma. She had surgery (“total excision”). Seven years later the peritoneal mesothelioma recurred and she had another surgery (“reexcision”). She remains well 15 years after the initial diagnosis. The patient did not receive chemotherapy.
See: Asensio, J.A., et al., Primary Malignant Peritoneal Mesothelioma: A Report of Seven Cases and a Review of the Literature, Arch Surg; Nov 1990, 125, 1477-1480.
17 + Years
In 1962, a 31 year-old woman had abdominal pain for several months and a mass was detected. She underwent exploratory laparotomy which found tumor nodules spread throughout her abdomen. The diagnosis of peritoneal mesothelioma was made. Complete surgical removal of the tumor was not possible. She was treated with radioactive phosphorus, radiation, and oral chemotherapy (cytoxan). She remained well for 17 years. In 1979 she had recurrent peritoneal mesothelioma. She was treated with cytoxan again and continued to live as of the writing of the published medical report.
Peritoneal Mesothelioma - Introduction
Peritoneal mesothelioma in the primary peritoneal mesothelial organizations and epithelial tumors, clinical rarely see.
Disease Arguments can be divided into adenomatous mesothelioma,cystic mesothelioma and peritoneal malignant mesothelioma(PMM).
The first two are benign. Cystic mesothelioma was particularly prevalent in women,
Cause unknown, occurred in the surrounding pelvic or attachments, a single or multiple cystic masses; patients often palpable abdominal mass and attendance. PMM about vicious Mesothelioma of 30%; in its close relationship with exposure to asbestos, about 5% of the patients have a history of exposure ; asbestos fibers after oral intake through Translocation to the wall and peritoneal disease. Exposure to asbestos from confirmed, the disease incubation period could be as long as 25 to 40 years. But from 1951 to 1993 domestic 20 reported 161 cases of the literature only one case of PMM a history of exposure to asbestos. In the absence of a history of exposure to asbestos in the crowd, the incidence rate of about 1 / 1 million years, Infection may be related to certain genetic factors. Reported one case of international, PMM patients more than 40 years ago dioxide contacts glial
Thorium (Thorotrast) .
PMM often occur in men over 40 years of age. Dirty floor or layer can be permanently and peritoneal tumor can be a direct violation of abdominal, pelvic Organ, 50% to 70% of the patients with lymph node and (or) blood distant metastasis such as liver, kidney, adrenal gland, lung, bone and lymph nodes, etc..
Clinical manifestations of this disease Lack of specificity, have abdominal pain, constipation, abdominal distension, weight loss and other intestinal obstruction performance. Physical or ascites can be found, such as abdominal mass. Ascites To exudate, some bloody. The disease often misdiagnosed as tuberculosis peritonitis and recurrent spontaneous bacterial peritonitis, mesenteric inflammation or peritoneal carcinomatosis Etc..
Ascites hyaluronic acid increased significantly,> 0.8 g / L found only PMM. Ascites exfoliated cells also check some value, but the result often difficult Judgement. -125 Serum carbohydrate antigen (CA125) increased help diagnose this disease .
B-ultrasound and CT performance varied, the typical irregular, peritoneal Thickening and omental adhesion was popular among hungry students, mesenteric a tissue sample; CT can also display enhanced Peripancreatic large mass, or intraperitoneal substantive diffuse large Mass, and bowel and mesenteric violations or peritoneal nodules, or a cystic mass, multi-with varying degrees of ascites .
Guided by ultrasound or CT wear Thorn biopsy a certain value. PMM diagnostic laparoscopy is a simple and effective method microscope peritoneum, omentum diffuse plaques and nodules, Open biopsy and pathological examination. We sent one case of 83-year-old male patient with laparoscopy, peritoneal biopsy report mesothelial cell hyperplasia, After immunohistochemical tests confirmed the PMM. Butchart, and so will be divided into four PMM: Phase I, confined to the peritoneal tumor; Ⅱ stage, tumor invasion Intra-abdominal lymph nodes; Ⅲ, tumor metastasis to the lymph nodes outside the abdominal cavity; Ⅳ period, blood distant metastasis. The above categories will help choose the method of treatment.
PMM has no effective standard treatment. Poor prognosis, the survival period after diagnosis in a median survival of more than two years of less than 20%. Main
Dioxin or died of intestinal obstruction of the death of little distant metastasis and tumor.
